Post-op fevers

 
 
“Wind, Water, Wound, Walk, Wonder Drugs”
Post-Op Day
Mnemonic
Cause
Key Clues / Examples
Typical Management
POD 0
-
- malignant hyperthermia
volatile anesthetic use, succinylcholine
intra-operatively or within first-hour post-anesthesia but may recur within 24h
POD 1–2
🌬 Wind
1) Atelectasis → Pneumonia

2) Trauma-related inflammation
Shallow breathing from pain, anesthesia, immobility → hypoventilation, fever, mild hypoxia
Incentive spirometry, ambulation, pulmonary toilet; if pneumonia suspected → CXR, sputum culture, antibiotics

expectant
POD 3–5
💧 Water
Urinary Tract Infection (UTI)
Foley catheter use or urinary stasis; dysuria, frequency, positive nitrite or leukocyte esterase
Urinalysis, urine culture → antibiotics; remove catheter early
POD 5–7
🩹 Wound
Surgical site infection (superficial or deep)
Local erythema, warmth, tenderness, pus; may have leukocytosis
Wound inspection, drainage, antibiotics
POD 5–10
🚶 Walk
Deep Vein Thrombosis (DVT) / Pulmonary Embolism (PE)
Immobility, calf pain/swelling, tachycardia, dyspnea
Doppler US, anticoagulation; DVT prophylaxis
POD 7–10+
💊 Wonder Drugs
Drug fever or abscess
Drug reaction (antibiotics, heparin, etc.) or late deep abscess
Discontinue suspect meds, CT scan if abscess suspected, drainage if needed
ETIOLOGY
NOTES
POD 0
POD 1-2
- atelectasis / PNA
- trauma-related inflammation
POD 3-5
UTI
POD 5-6
DVT
POD 7
Incision site
POD 8-15
Deep abscess
 
While these early fevers have been classically attributed to atelectesis a more contemporary view is that fevers in the first two days of surgery are due to trauma-related inflammation (Pile, 2006). It is fairly uncommon for patients to present with an infectious fever before post-operative day 2.  Urinary tract infections might be diagnosed as early as post-operative day 2, while wound infections and cerebritis would be unlikely to present before post-operative day 4.  Malignant hyperthermia rarely presents more than 6 hours after administration of inhaled anesthetics or succinylcholine.  `